The highest honor bestowed by the U.Va. Patent Foundation, the Edlich-Henderson Inventor of the Year award each year recognizes an inventor or team of inventors whose research discoveries have proven to be of notable value to society. Profs. Macdonald and Lynch were honored for their achievements in modulating the activity of two of the body’s naturally occurring signaling molecules, sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA). The inventors have developed a number of small molecules that mimic or block S1P and LPA at their receptors and thereby offer tremendous potential therapeutic benefits.