Events & Seminars > Event Details


4:00 pm
Room 304, Chemistry Building

Targeted and Serendipitous Discovery of New Reactions


Professor Mitch Croatt
University of North Carolina at Greensboro

Hosted by: Professors Mike Hilinski and Rebecca Pompano

Abstract:  In order to approach the ideal synthesis, my research group is focused on reducing the number of steps required to synthesize molecules.  To optimally do so, we are 1) designing new reactions that add significant molecular complexity to the molecules, 2) using function-oriented synthesis to simplify structures without sacrificing the activity of the molecule, and 3) using late-stage diversification to produce more analogues in a more rapid fashion.  Towards these ends, I will first be presenting some of our results to generate cyanocarbenes from alkynes and azides.  I will also present my groups’ synthesis of clinprost, which utilized all three of these step-saving approaches, in addition to some fortuitous reaction discovery, to yield the shortest synthesis of clinprost and its analogues.

Biosketch:  Mitch Croatt grew up in Minnesota and did undergraduate research in the lab of George O’Doherty.  He then did his Ph.D. with Paul Wender at Stanford University and postdoctoral research with Erick Carreira at ETH-Zurich.  He started his academic career at UNC-Greensboro in 2010 and has recently been promoted to associate professor.  He has mentored more than 35 researchers, has won teaching awards from UNC-Greensboro, and has been funded with ACS-PRF, NSF CAREER, and NIH grants.