Events & Seminars > Event Details


4:00 pm
Room 304, Chemistry Building

Expanding Small-Molecule Diversity for Discovering Novel Probes and Therapeutics


Professor Damian Young
Baylor College of Medicine

Hosted by: Professor Ken Hsu

Diversity-oriented synthesis (DOS) is a guiding concept for the synthesis of biologically active small molecules that more effectively sample chemical space. Our efforts have used DOS as an inspiration to develop new chemical methods that yield novel molecular structures.  We are also using DOS in the area of fragment-based ligand discovery (FBLD) toward generating low molecular weight but highly efficient binders to protein targets.  In addition to their broader target scope, fragments derived from DOS can be rapidly chemically optimized to potent and selective lead compounds.

Damian Young is a Assistant Director for the Center for Drug Discovery at Baylor College of Medicine.  He is also a faculty member within the Departments of Pharmacology and Pathology and Immunology. His research focuses on the development of chemical pathways leading to molecule that  can be used to probe fundamental and disease-associated biology. His lab is pioneering new chemical and biophysical methodologies related to fragment-based drug discovery to be deployed against challenging targets in cancer.