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4:00 pm
Room 304, Chemistry Building

Coordination compounds with biological relevant ligands. Structural, electronic, magnetic and chiral versatility


Professor Norah Barba-Behrens
Departamento de Quimica Inorganica Facultad de Quimica Universidad Nacional Autonoma de Mexico

Hosted by: Professor Cassandra Fraser

Transition metal compounds with biological active ligands have shown that, when coordinated to a metal ion, may present a synergistic effect, modification or enhancing of the original activity. The bonding mode, structure, and weak interactions are relevant to the biological activity of coordination compounds with imidazole derivatives. Intramolecular lone pair •••π interactions, play an important role in the stabilization of biologically active complexes. On the other hand, intermolecular interactions, such as O-N-O•••π and Cl•••π give place to a variety of supramolecular arrangements.
The structural, electronic, magnetic properties and biological activity were investigated for a series of cobalt(II), nickel(II) and copper(II) coordination compounds of azole and chiral aminoalcohol derivatives with different substituents, as NO2, SO2 or OCO.

Copper (II) coordination compounds of ronidazole (carbamate chelate), tinidazole (intramolecular lone pair S=O•••π) and with the chiral N-carboxylate ephedrine (anagostic H•••Cu)
[1] S. Betanzos-Lara, N. P. Chmel, M. T. Zimmerman, L. R. Barrón-Sosa, C. Garino, L. Salassa, A. Rodger, J. L. Brumaghim, I. Gracia-Mora, N. Barba-Behrens, Dalton Transactions, 44 (2015) 3673; [3] P. García-Holley, N. Ortiz-Pastrana, R. A. Toscano, M. Flores-Álamo, N. Barba-Behrens, Polyhedron, 104 (2016) 127. [3] C. Crisóstomo-Lucas, P. García-Holley, S. Hernández-Ortega, F. Sánchez-Bartéz, I. Gracia-Mora, N. Barba-Behrens, Inorg. Chim. Acta, 438 (2015) 245; [4] I. Alfaro-Fuentes, H. López-Sandoval, E. Mijangos, A. M. Duarte-Hernández, G. Rodriguez-López, M. I. Bernal-Uruchurtu, R. Contreras, A. Flores-Parra, N. Barba-Behrens, Polyhedron, 67 (2014) 373. Finacial support by DGAPA-UNAM 222713 and Conacyt CB-2012 178851