Events & Seminars > Upcoming Events & Seminars

Confessions of a cunning collaborator: Strategies for sustaining a successful research agenda at a PUI

Are you considering a career in academia and curious to learn more about the nature of research at a predominantly undergraduate institution (PUI)?  Strategies that have proven effective in sustaining a robust scholarly agenda while also affording opportunities to establish rich mentoring relationships with undergraduate students will be shared.  Approaches have included collaboration with partners […]

Redefining druggability using chemoproteomic platforms

The Nomura Research Group is focused on developing and applying chemoproteomic platforms to drug the undruggable proteome to develop next-generation disease therapies. One of the greatest challenges that we face in discovering new disease therapies is that most proteins are considered “undruggable” or difficult to target with small-molecules. Our research group addresses this challenge by […]

A proton-coupled electron transfer viewpoint on bond activation electrocatalysis and nanocrystals

Electrochemical power for future Army

From basic chemistry to new opioid biology

The worldwide opioid crisis has occasioned efforts to develop new opioids for both existing uses (pain control) as well as new indications (itch, addiction). We have focused on the discovery of compounds able to selectively activate one of the two main intracellular pathways associated with the kappa opioid receptor. This type of activity, called “functional […]

Once Upon a Time in Kamchatka: The Extraordinary Search for Natural Quasicrystals

Quasicrystals are exotic materials that have symmetries that were once thought to be impossible for matter. The first known examples were synthesized in the laboratory over 30 years ago, but could Nature have beaten us to the punch? This talk will describe the search that took over a dozen years to answer this question, resulting […]

New recipes for biocatalysis: Expanding the cytochrome P450 chemical landscape

Assembly and disassembly of layered materials

Layered solids – which have strong bonds in two dimensions and weaker links in the third – are interesting building blocks for materials and devices because they potentially offer control over structure at the molecular level.  Our research in this area began with the question of whether such compounds could be built up one layer […]

Searching for selective catalytic reactions in complex molecular environments

This lecture will describe recent developments in our efforts to develop low-molecular weight catalysts for asymmetric reactions.  Over time, our view of asymmetry has ebbed and flowed, with foci on enantioselectivity, site-selectivity and chemoselectivity.  In most of our current work, we are studying issues of enantioselectivity as a prelude to extrapolation of catalysis concepts to […]

Designing nanoparticles for sustainability

Engineered nanoparticles are increasingly being incorporated into devices and products across a variety of commercial sectors – this means that engineered nanoscale materials will either intentionally or unintentionally be released into the ecosystem. The long-term goal of the presented work is to understand the molecular design rules that control nanoparticle toxicity using aspects of materials […]

Transition metal catalyzed hydroarylation of Olefins: New catalysts for alkyl and alkenyl arenes

The selective catalytic functionalization of C–H bonds of hydrocarbons remains one of the foremost challenges facing synthetic chemists. Processes that convert C–H bonds of simple hydrocarbons into new C–C bonds are particularly important. For example, alkyl and alkenyl arenes are currently produced on a scale of billions of pounds per year, and the addition of […]

Expanding the imaging toolbox

Imaging tools have revolutionized our understanding of living systems by enabling researchers to “peer” into tissues and cells and visualize biological features in real time.  While powerful, these probes have been largely confined to monitoring cellular behaviors on a microscopic level.  Visualizing cellular interactions and functions across larger spatial scales—including those involved in cell migration […]

Activity assisted self-assembly of colloidal particles

Active matter is one of the most exciting fields in soft condensed matter today. The collective behavior and dynamics of catalytically activated colloidal particles and microstructures immersed in active fluids (e.g. bacteria or artificial micro-swimmers) have recently drawn great interest in a broad multidisciplinary scientific community. In fact, the interplay between active and thermal forces, […]

Excited States of Transition Metal Complexes: From Basic Science Toward Therapy

Excited state processes of transition metal complexes initiated by the absorption of light have potential applications in various fields, such as photochemotherapy (PCT) and solar energy conversion. These reactions include photoinduced ligand exchange, charge transfer, photoisomerization, and energy transfer to produce 1O2. In the case of Ru(II) and Rh2(II,II) complexes, the relative energies of the […]

Rare cell diagnostics

We have developed a method for isolating rare cells, such as circulating tumor cells (CTCs) and fetal cells, in blood based on positive selection, where cell-surface markers are labeled with fluorescent antibodies, ranked by aliquots, and sorted. We call this process ensemble-decision aliquot ranking (eDAR), because we perform the ranking by looking at an ensemble […]

Structural and dynamic studies of supramolecular assemblies by solid-state NMR spectroscopy

I will present recent work from my lab on the development and applications of magic-angle spinning solid-state nuclear magnetic resonance (NMR) techniques toward the structural and dynamic analysis of supramolecular protein and protein-DNA assemblies. The main topics will include: (1) new paramagnetic solid-state NMR methodologies for the rapid determination of three-dimensional protein structures and (2) […]

ChemoProteomic Adventures in Nucleotide Binding Space

Protein kinases represent the single largest mammalian enzyme family with ~ 518 members in the human proteome.  These enzymes have been implicated in a wide array of complex cellular functions and pathways, ranging from metabolic regulation to tumorigenesis.  Assessing kinase function in vivo is complicated by a high degree of post-translational regulation, generally low expression […]

Seeing is Believing: Biological imaging with genetically encoded fluorescent and bioluminescent reporters

Biological signaling occurs at different levels, but basic processes are largely chemically based. Our research is focused on the engineering of novel molecular probes to peer into cells and brains to understand their communications. In this talk, I will discuss several genetically encoded fluorescent biosensors for imaging redox dynamics, including the redox status of an important cellular […]

Observational constraints on the anthropogenic sources, chemistry, and air quality and climate impacts of atmospheric nitrogen oxides

Atmospheric nitrogen oxides affect global climate, air quality, and ecosystem nutrient cycling. For example, nitrous oxide (N2O) is a potent, long-lived greenhouse gas (lifetime ~ 100 years), and reactive nitrogen oxides, including NOx (≡ NO + NO2) and its chemical products, regulate the oxidative capacity of the troposphere. Nitrogen oxides are emitted though various anthropogenic […]

Colloidal Metal Nanocrystals: From Academic Studies to Industrial Applications

Although the first documented synthesis of colloidal metal nanocrystals can be traced back to the beautiful work on gold colloids by Michael Faraday in 1856, only within the last decade have methods become available for generating samples with the quality, quantity, and reproducibility needed for a systematic study of their properties as a function of […]

Molecular Examples of Iron(II) to Titanium(IV) Charge Transfer: Relevance to Dye-Sensitized Solar Cells, Blue Sapphire, and Moon Rocks

Iron(II)-to-titanium(IV) metal-to-metal-charge transfer (MMCT) is important in the photosensitization of TiO2 by ferrocyanide, charge transfer in solid-state metal-oxide photocatalysts, and has been invoked to explain the blue color of sapphire, blue kyanite, and some lunar material, yet molecular examples of this phenomenon have not been investigated. We have prepared a series of complexes with alkynyl […]

Coordination compounds with biological relevant ligands. Structural, electronic, magnetic and chiral versatility

Transition metal compounds with biological active ligands have shown that, when coordinated to a metal ion, may present a synergistic effect, modification or enhancing of the original activity. The bonding mode, structure, and weak interactions are relevant to the biological activity of coordination compounds with imidazole derivatives. Intramolecular lone pair •••π interactions, play an important […]

Research with Undergraduates: A Fabulous Career

In this talk I will discuss my group’s research in computational chemistry, spanning atmospheric, biological, medicinal, and physical chemistry. More than 110 undergraduates have contributed to these projects, and I will include examples of how student interest and initiative drove our undergraduate research program forward. The benefits of early introduction to research and the development […]

N-Heterocyclic Carbenes: Effective Tools for Small Molecules Stabilization

The chemistry of s- and p- block elements has evolved dramatically in recent decades, catalyzed by the discovery of stable carbenes. One of the most prominent uses of carbenes is as synthetic tools to aid in the stabilization of highly reactive small molecules. This presentation will cover the syntheses and molecular structures of Nheterocyclic carbene-stabilized […]

Capturing instructional practices in the chemistry classrooms and laboratories: New research-based tools to address both instructors’ and researchers’ needs

Within the last ten years, there has been a growing interest in transforming the instructional practices in science courses at the university level. As the variety of pedagogical professional development efforts expand, there is an increasing need to quantify teaching practices. Stakeholders may be interested in monitoring changes over time, comparing instructional practices between instructors […]

Quantitative Proteomics for Understanding Modified Proteins and Proteomes

Mass spectrometry has become a powerful tool for characterization of thousands of proteins from any cellular source. Here in this presentation, I will highlight advances in mass spectrometry based methodology to detect post-translational modifications on histone proteins involved in epigenetic regulation of gene expression, identify RNA-protein interaction domains and understand the dynamics of non-histone acetylated […]

Molecular Examples of Iron(II) to Titanium(IV) Charge Transfer: Relevance to Dye-Sensitized Solar Cells, Blue Sapphire, and Moon Rocks

Iron(II)-to-titanium(IV) metal-to-metal-charge transfer (MMCT) is important in the photosensitization of TiO2 by ferrocyanide, charge transfer in solid-state metal-oxide photocatalysts, and has been invoked to explain the blue color of sapphire, blue kyanite, and some lunar material, yet molecular examples of this phenomenon have not been investigated. We have prepared a series of complexes with alkynyl […]

Chemical Tricks for Tackling Undruggable Targets

Somatic mutations in the small GTPase K-Ras are the most common activating lesions found in human cancer, and are generally associated with poor response tostandard therapies. Efforts to directly target this oncogene have faced difficulties due to its picomolar affinity for GTP/GDP and the absence of known allosteric regulatory sites. Oncogenic mutations result in functional activation of […]

Redox catalysis for radical reactions of complex molecules

Single electron transfer (SET) processes – frequently utilized by Nature to activate its substrates – significantly enhance the reactivity of organic molecules. These SET reactions provide facile access neutral radicals – reactive intermediates that are particularly attractive for use in complex settings as a consequence of their general lack of reactivity with polar functional groups. […]

Redesigning Escherichia coli to Produce 1,3-Propanediol at Commercial Scale

Professor Nigel S. Dunn-Coleman President and CEO AlerGenetica SL, Tenerife, Canary Islands, Spain Biotechnology affilations Genencor (a biotechnology subsidiary of DuPont, located in Palo Alto, CA) for 20 years with last role as Research & Development program leader. Also responsible for Genencor’s fungal genomic collaborations and the development of fungal production strains. DuPont (E. I. […]