Assistant Professor
jjc5p@virginia.edu
Room 386A, Chemistry Building
(434) 243-2131
B.S. University of Arizona, 1997
Ph.D. University of Pennsylvania, 2003
N.I.H. Post-doctoral Research Fellow, Columbia University (Prof. R. Breslow), 2003-2005
My research group is interested in the interplay between the development of new synthetic methods and the modulation of biomolecular interactions. Biologically active natural products both motivate the invention of new and more efficient means for the construction of structurally complex molecular architectures and provide critical structure-activity information on important biological targets. Alternatively, the discovery of new biomolecular interactions with import to human health inspire the synthesis of unique small molecule scaffolds designed to either inhibit or stimulate the associated biological response. Research efforts in the Chruma group focus on the discovery of efficient C–C bond-forming transformations for the rapid construction of biologically active natural products as well as designed small molecule peptidomimetic scaffolds that explore untapped regions of chemical space. We are particularly interested in the discovery of small molecule modulators of protein-protein interactions and cell-signaling events involved in cellular differentiation and epithelial cancer cell metastasis.
Exploring the Original Proposed Biosynthesis of (+)-Symbioimine: Remote Exocyclic Stereocontrol in a Type I IMDA Reaction. Burke JP, Sabat M, Iovan DA, Myers WH, Chruma JJ. Org Lett. 12:3192-5. (2010).
Iron control of erythroid development by a novel aconitase-associated regulatory pathway. Bullock GC, Delehanty LL, Talbot AL, Gonias SL, Tong WH, Rouault TA, Dewar B, Macdonald JM, Chruma JJ, Goldfarb AN. Blood. in press (2010)
Palladium-catalyzed decarboxylative benzylation of diphenylglycinate imines. Fields WH, Chruma JJ. Org Lett. 12:316-9 (2010).
Azaphilone alpha-Bromoacetates (Az-alpha-Bs): Fluorescent Linchpin Reagents for the Inter- and Intramolecular Cross-Linkage of Primary Amines to Thiols. Chruma JJ, Moon S-J, Sanford Jr. WE. Lett. Org. Chem. 6, 367-371 (2009).
