Field, Denise

Denise Field

Specialization in Biochemistry Research with Prof. Timothy Macdonald

Denise is from Haymarket, VAand graduated from Osbourn Park High School.  She has worked under Professor Timothy Macdonald since Fall 2009 synthesizing small molecule inhibitors for the Sphingosine kinases.  Many cancer cell lines have an overexpression of sphingosine 1-phosphate which is the product of the sphingosine kinases.  There are two forms of the sphingosine kinases, SK1 and SK2.  Compounds selective for SK1 with nanomolar potencies have been synthesized by the Macdonald Lab and they are currently working on finding such an inhibitor for SK2 as well as a dual inhibitor for both isoforms.