Salamoun, Joseph

Joseph Salamoun

Specialization in Biochemistry
Research with Prof. Tim Macdonald

I am currently in my second year of research in the Macdonald lab. The aim of our research is to create drug-like molecules that have favorable biological activity and good uptake by the human body with minimal to no side effects. Overall, the project involves the collaboration of various disciplines including enzymology, chemistry, and microbiology both at the University of Virginia School of Medicine and Department of Chemistry. My research is primarily focused on the synthesis of new analogues to explore the structure-activity relationship of Nitazoxanide (NTZ). NTZ is currently an FDA approved drug, used to treat infections caused by Giardia intestinalis and Cryptosporidium parvum. Specifically, the goal is to improve the biological activity and solubility of NTZ as well as broaden its application to other serious human diseases (Tuberculosis, Hepatitis).