Taylor Koerner

Taylor Koerner

Specialization in Biochemistry
Research with Prof. Tim Macdonald

Taylor has been working in the Macdonald Laboratory since his second year. His work focuses on the synthesis and purification of derivatives of the antibiotic Nitazoxanide (NTZ). NTZ is an active antibacterial and anti-protozal drug that has activity against many pathogenic bacteria including Clostridium difficile, Staphylococcus aureus, and Campylobacter jejuni. This project has sought to improve the activity of NTZ against these and other targets. Taylor has employed various synthetic approaches, including amide chemistry, the Suzuki-Miyaura cross coupling reaction, and a novel synthesis of an imidazole head-group (Region D) in order to accomplish this goal. In addition to synthesizing analogues, Taylor has also had a role in characterizing the target of NTZ in S. aureus by performing experiments in Dr. Paul Hoffman’s Laboratory in the UVA Medical School. Taylor is an avid cyclist and this past summer biked from Charlottesville to Chicago and plans to spend the coming summer biking down the West Coast from Vancouver, BC to Mexico.

 

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