Gnade, Colette

Colette Gnade

Bachelor's of Science Degree with Specialization in Biochemistry.
Research with Prof. John Bushweller.

Colette attended Waukee High School in Waukee, IA.  She is pursuing a B. Sc. degree in Chemistry with a Specialization in Biochemistry.  Her research is with John Bushweller in the Department of Molecular Physiology and Biological Physics.

A little bit about what they are doing:

Mixed Lineage Leukemia translocations account for 5-10% of acute leukemias, usually of poor prognosis. Of the possible 60 fusion parntners, AF4, a transcriptional activator, accounts for a majority of these in-frame fusion proteins with MLL. These fusions result in the upregulation of HOX genes, which are carefully monitored in normal blood cell development, and increase expression of hematopoietic progenitors. However, the recruitment of transcriptional machinery to DNA in fusion protein leukemogenesis is unknown. Therefore, our goal is to characterize the interactions of AF4-MLL fusion proteins with transcriptional complexes including P-Tefb, a complex of Cyclin and Cyclin-Dependent Kinase, in order to target their leukemogenic potential.

Colette is a track and field team member and a Lawn Resident.