Tomlinson, Jennifer

Jennifer Tomlinson

Bachelor's of Science Degree with Specialization in Biochemistry.
Research with Prof. Tim Macdonald.

I am from Gainesville, Florida and attended Eastside High School.  I am pursuing a Bachelor’s of Science Degee in Chemistry with a Specialization in Biochemistry.  My research mentor is Timothy Macdonald in the Department of Chemsitry.

Clostridium difficile is a Gram-positive bacteria that causes inflammation and swelling in the large intestine.  Patients with a C. Difficile Infection (CDI), after having been treated with broad-spectrum antibiotics, have reduced amounts of beneficial gut flora, leaving behind toxic levels of C. difficile. The emerging threat of C. difficile infection is a major risk for hospitals, assisted living facilities and nursing homes. Nitazoxanide (NTZ), an FDA approved antimicrobial for treatment of intestinal infections caused by parasitic C. parvum and G. lamblia, can also be used to treat a CDI.  However, NTZ lacks the efficacy to be of significance in many infectious cases. The Macdonald research group, in association with the Hoffman research group at the UVA Medical School, has developed potential news drugs that surpass NTZ in both bioavailability and efficacy. We are in the process of developing and optimizing reaction routes toward the synthesis of these analogues. These analogues will undergo in vitro minimum inhibitory concentration (MIC) testing for bioavailability and in vivo experiments using a mouse crisis model against the current standard of care.